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Article

Tumor promotion and inhibition by phenobarbital in livers of conditional Apc-deficient mice.

Archives of toxicology - 1 Jun 2016

Braeuning Albert, Gavrilov Alina, Geissler Miriam, Wenz Christine, Colnot Sabine, Templin Markus F, Metzger Ute, Römer Michael, Zell Andreas, Schwarz Michael

Abstract excerpt

Activation of Wnt/β-catenin signaling is important for human and rodent hepatocarcinogenesis. In mice, the tumor promoter phenobarbital (PB) selects for hepatocellular tumors with activating β-catenin mutations via constitutive androstane receptor activation. PB-dependent tumor promotion was studied in mice with genetic inactivation of Apc, a negative regulator of β-catenin, to circumvent the problem of randomly...

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Identifiers

PMID: 26838046
DOI: 10.1007/s00204-016-1667-1

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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