Article
Conditional deletion of beta-catenin reveals its role in liver growth and regeneration.
Gastroenterology - 1 Nov 2006
Tan Xinping, Behari Jaideep, Cieply Benjamin, Michalopoulos George K, Monga Satdarshan P S
Abstract excerpt
BACKGROUND & AIMS: The Wnt/beta-catenin pathway plays a role in liver growth and development. To address this conclusively, we used a conditional knockout approach to delete beta-catenin in the liver. METHODS: Floxed beta-catenin (exons 2-6) mice were intercrossed with Albumin-Cre recombinase transgenic mice; considerable beta-catenin deletion was evident 15 days after birth by Western blot and...
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