Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Hepatocyte growth factor/ <i>c-met</i> signaling pathway is required for efficient liver regeneration and repair

30 Mar 2004

Abstract excerpt

Hepatocyte growth factor/scatter factor c-met signaling pathway is of central importance during development as well as in tumorigenesis. Because homozygous null mice for either hgf/sf or c-met die in utero, we used Cre/loxP-mediated gene targeting to investigate the function of c-met specifically in the adult liver. Loss of c-met appeared not to be detrimental to hepatocyte function under physiological...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Liver physiology and pathology
Share to Organ Transplantation Techniques and Outcomes
Share to Pancreatic and Hepatic Oncology Research

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Source

Identifiers

PMID: 15070743
DOI: 10.1073/pnas.0306068101

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Hepatocyte growth factor/ <i>c-met</i> signaling pathway is required for efficient liver regeneration and repairPMID 15070743Read ↗

Met provides essential signals for liver regeneration.Semantic proximity Read ↗

Scatter factor/hepatocyte growth factor is essential for liver development.Semantic proximity Read ↗

Biological roles of hepatocyte growth factor‑Met signaling from genetically modified animals (Review)Semantic proximity Read ↗

Hepatocyte specific deletion of c-Met leads to the development of severe non-alcoholic steatohepatitis in miceSemantic proximity Read ↗

c-Met is essential for wound healing in the skin.Semantic proximity Read ↗

Mutation in collagen-1 that confers resistance to the action of collagenase results in failure of recovery from CCl4-induced liver fibrosis, persistence of activated hepatic stellate cells, and diminished hepatocyte regeneration.Semantic proximity Read ↗

Conditional deletion of beta-catenin reveals its role in liver growth and regeneration.Semantic proximity Read ↗

Biological effects of targeted inactivation of hepatocyte growth factor-like protein in mice.Semantic proximity Read ↗

Wnt/-Catenin Signaling and Liver Regeneration: Circuit, Biology, and OpportunitiesSemantic proximity Read ↗

Gene of the month: <i>HGF</i>Semantic proximity Read ↗

HGF/c-MET Axis in Tumor Microenvironment and Metastasis FormationSemantic proximity Read ↗

Loss of hepatocyte cell division leads to liver inflammation and fibrosisSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.