Article
Phosphoinositide 3-kinase Akt signaling pathway interacts with protein kinase Cbeta2 in the regulation of physiologic developmental hypertrophy and heart function.
American journal of physiology. Heart and circulatory physiology - 1 Mar 2009
Rigor Debra L, Bodyak Natalya, Bae Soochan, Choi Jun H, Zhang Li, Ter-Ovanesyan Dmitry, He Zhiheng, McMullen Julie R, Shioi Tetsuo, Izumo Seigo, King George L, Kang Peter M
Abstract excerpt
The phosphoinositide 3-kinase (PI3-kinase)-protein kinase B (Akt) signaling pathway is essential in the induction of physiological cardiac hypertrophy. In contrast, protein kinase C beta2 (PKCbeta2) is implicated in the development of pathological cardiac hypertrophy and heart failure. Thus far, no clear association has been demonstrated between these two pathways. In this study, we examined the potential...
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