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Article

Temporally controlled overexpression of cardiac-specific PI3Kalpha induces enhanced myocardial contractility--a new transgenic model.

American journal of physiology. Heart and circulatory physiology - 1 Oct 2008

Yano Naohiro, Tseng Andy, Zhao Ting C, Robbins Jeffrey, Padbury James F, Tseng Yi-Tang

Abstract excerpt

The phosphatidylinositol 3-kinase (PI3K) signaling pathway regulates multiple cellular processes including cell survival/apoptosis and growth. In the cardiac context, PI3Kalpha plays important roles in cardiac growth. We have shown that cardiac PI3K activity is highly regulated during development, with the highest levels found during the fetal-neonatal transition period and the lowest levels in the adult. There...

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Identifiers

PMID: 18723766
DOI: 10.1152/ajpheart.00531.2008
PMCID: PMC2593510

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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