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Article

Dosage-dependent effects of Akt1/protein kinase Balpha (PKBalpha) and Akt3/PKBgamma on thymus, skin, and cardiovascular and nervous system development in mice.

Molecular and cellular biology - 1 Dec 2005

Yang Zhong-Zhou, Tschopp Oliver, Di-Poï Nicolas, Bruder Elisabeth, Baudry Anne, Dümmler Bettina, Wahli Walter, Hemmings Brian A

Abstract excerpt

Akt/protein kinase B (PKB) plays a critical role in the regulation of metabolism, transcription, cell migration, cell cycle progression, and cell survival. The existence of viable knockout mice for each of the three isoforms suggests functional redundancy. We generated mice with combined mutant alleles of Akt1 and Akt3 to study their effects on mouse development. Here we show that Akt1-/- Akt3+/- mice display...

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Identifiers

PMID: 16287854
DOI: 10.1128/MCB.25.23.10407-10418.2005
PMCID: PMC1291243

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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