Article
GAB2 gene does not modify the risk of Alzheimer's disease in Spanish APOE 4 carriers.
The journal of nutrition, health & aging - 1 Mar 2009
Ramirez-Lorca R, Boada M, Saez M E, Hernandez I, Mauleon A, Rosende-Roca M, Martinez-Lage P, Gutierrez M, Real L M, Lopez-Arrieta J, Gayan J, Antunez C, Gonzalez-Perez A, Tarraga L, Ruiz A
Abstract excerpt
OBJECTIVES: The genetic basis of Alzheimer's disease (AD) is being analyzed in multiple whole genome association studies (WGAS). The GAB2 gene has been proposed as a modifying factor of APOE epsilon 4 allele in a recent case-control WGAS conducted in the US. Given the potential application of these novel results in AD diagnostics, we decided to make an independent replication to examine the GAB2 gene effect in...
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