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Article

Association study of the GAB2 gene with the risk of developing Alzheimer's disease.

Neurobiology of disease - 1 Apr 2008

Chapuis Julien, Hannequin Didier, Pasquier Florence, Bentham Peter, Brice Alexis, Leber Isabelle, Frebourg Thierry, Deleuze Jean-François, Cousin Emmanuelle, Thaker Uma, Amouyel Philippe, Mann David, Lendon Corinne, Campion Dominique, Lambert Jean-Charles

Abstract excerpt

The first genome-wide association in Alzheimer's disease (AD) suggested that the GAB2 gene rs2373115 polymorphism may be a strong risk factor in APOE varepsilon4-carriers. We failed to detect an association of rs2373115 with the risk of developing AD in three populations (totalling 1406 controls and 1749 AD cases) whatever the APOE status, even if we observed a slight tendency for an increase of the GG genotype...

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Source

Identifiers

PMID: 18272374
DOI: 10.1016/j.nbd.2007.12.006

Genes

GAB2
APOE

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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