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Article

Role of the N-acetyltransferase 2 detoxification system in thyroid cancer susceptibility.

Clinical cancer research : an official journal of the American Association for Cancer Research - 1 Jan 2009

Guilhen Ana C T, Bufalo Natassia E, Morari Elaine C, Leite Janaina L, Assumpcao Ligia V M, Tincani Alfio J A, Ward Laura S

Abstract excerpt

PURPOSE: Genetic polymorphisms in genes encoding for enzymes involved in the biotransformation of carcinogens have been shown to be relevant as risk for cancer and may be of considerable importance from a public health point of view. Considering that N-acetyltransferase 2 (NAT2) polymorphisms modulate the response to ionizing radiation, the strongest risk factor recognized to cause differentiated thyroid cancer...

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Source

Identifiers

PMID: 19118072
DOI: 10.1158/1078-0432.CCR-08-1835

Genes

NAT2
GSTM1
GSTP1
GSTT1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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