Article
Polymorphism of the N-acetyltransferase 2 gene, red meat intake, and the susceptibility of hepatocellular carcinoma.
The American journal of gastroenterology - 1 Jun 2003
Huang Yi-Shin, Chern Herng-Der, Wu Jaw-Ching, Chao Yee, Huang Yi-Hsiang, Chang Full-Young, Lee Shou-Dong
Abstract excerpt
OBJECTIVE: Carcinogenic aromatic amines, derived from cooked meat, are activated or inactivated by hepatic N-acetyltransferase (NAT). The aim of this study was to evaluate the relationship of NAT2 genetic polymorphisms with hepatocellular carcinoma (HCC), with special reference to the interaction of dietary habits. METHODS: Peripheral white blood cell DNA from 185 HCC patients and 185 matched controls were...
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