N-acetyltransferase NAT1 and NAT2 genotypes and lung cancer risk.

doi:10.1097/00008571-199808000-00002

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Article

N-acetyltransferase NAT1 and NAT2 genotypes and lung cancer risk.

Pharmacogenetics - 1 Aug 1998

Bouchardy C, Mitrunen K, Wikman H, Husgafvel-Pursiainen K, Dayer P, Benhamou S, Hirvonen A

Abstract excerpt

Acetyltransferases, encoded by the NAT1 and NAT2 genes, are involved in the activation/inactivation reactions of numerous xenobiotics, including tobacco-derived aromatic amine carcinogens. Several allelic variants of NAT1 and NAT2, which cause variations in acetylation capacity, have been detecte...

Topics

Acetyltransferases
Arylamine N-Acetyltransferase
Biomarkers, Tumor
Female
Genotype
Humans
Isoenzymes
Lung Neoplasms
Male
Middle Aged
Risk Factors
Smoking

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