N-Acetyltransferase 2 polymorphisms, cigarette smoking and alcohol consumption, and oral squamous cell cancer risk.

doi:10.1093/carcin/22.12.1993

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Article

N-Acetyltransferase 2 polymorphisms, cigarette smoking and alcohol consumption, and oral squamous cell cancer risk.

Carcinogenesis - 1 Dec 2001

Chen C, Ricks S, Doody D R, Fitzgibbons E D, Porter P L, Schwartz S M

Abstract excerpt

The risk of squamous cell cancers of the oral cavity (OSCC) is strongly related to the use of tobacco and alcohol. N-Acetyl transferases 1 and 2 (NAT2) metabolize aryl- and heterocyclic amines that are present in tobacco smoke. NAT2 slow acetylator phenotype or genotype is related to reduced ability to detoxify these xenobiotics that are carcinogenic in tissues in which smoking-related cancers develop (e.g....

Topics

Adolescent
Adult
Aged
Alcohol Drinking
Arylamine N-Acetyltransferase
Female
Genetic Predisposition to Disease
Humans
Male
Mouth Neoplasms
Neoplasms, Squamous Cell
Odds Ratio
Polymorphism, Genetic
Risk Factors
Smoking
Tars

Source

Open in PubMed

Identifiers

PMID: 11751430
DOI: 10.1093/carcin/22.12.1993

Genes

NAT2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026.

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