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Article

NAT2 slow acetylator genotype as an important modifier of breast cancer risk.

International journal of cancer - 20 Apr 2005

Sillanpää Pia, Hirvonen Ari, Kataja Vesa, Eskelinen Matti, Kosma Veli-Matti, Uusitupa Matti, Vainio Harri, Mitrunen Katja

Abstract excerpt

N-acetyltransferase 2 (NAT2) is a polymorphic enzyme participating in the metabolism of numerous pharmaceutical drugs and carcinogens found in tobacco smoke and diet. The NAT2 gene is highly polymorphic and several different allelic variants exist that determine the acetylator phenotype. In the course of our case-control study, we developed a new method based on fluorogenic allele-specific probes for analyzing...

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Source

Identifiers

PMID: 15609332
DOI: 10.1002/ijc.20677

Genes

NAT2

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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NAT2 slow acetylator genotype as an important modifier of breast cancer risk.PMID 15609332Read ↗

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NAT2 polymorphisms combining with smoking associated with breast cancer susceptibility: a meta-analysis.Semantic proximity Read ↗

A meta-analysis of the association of N-acetyltransferase 2 gene (NAT2) variants with breast cancer.Semantic proximity Read ↗

Landscape of NAT2 polymorphisms among breast cancer.Semantic proximity Read ↗

Cigarette smoking, N-acetyltransferase 2 genotypes, and breast cancer risk: pooled analysis and meta-analysis.Semantic proximity Read ↗

NAT2 slow acetylation and GSTM1 null genotypes may increase postmenopausal breast cancer risk in long-term smoking women.Semantic proximity Read ↗

Differential effect of NAT2 on the association between active and passive smoke exposure and breast cancer risk.Semantic proximity Read ↗

Association between N-acetyltransferase 2 (NAT2) genetic polymorphism and development of breast cancer in post-menopausal Chinese women in Taiwan, an area of great increase in breast cancer incidence.Semantic proximity Read ↗

The association of polymorphic N-acetyltransferase (NAT2) with breast cancer risk.Semantic proximity Read ↗

N-acetyltransferase 2 polymorphism and breast cancer risk with smoking: a case control study in Japanese women.Semantic proximity Read ↗

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