Article
Opposing effects of HLA-DRB1*13 alleles on the risk of developing anti-citrullinated protein antibody-positive and anti-citrullinated protein antibody-negative rheumatoid arthritis.
Arthritis and rheumatism - 1 Apr 2009
Lundström Emeli, Källberg Henrik, Smolnikova Marina, Ding Bo, Rönnelid Johan, Alfredsson Lars, Klareskog Lars, Padyukov Leonid
Abstract excerpt
OBJECTIVE: The effect of non-shared epitope HLA-DRB1 alleles on rheumatoid arthritis (RA) is poorly understood. This study was undertaken to investigate the effects of several HLA-DRB1 alleles, independent of the shared epitope, on the risk of developing anti-citrullinated protein antibody (ACPA)-positive or ACPA-negative RA in a large case-control study. METHODS: HLA typing for the DRB1 gene was performed in...
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