Article
Origin of the voltage dependence of G-protein regulation of P/Q-type Ca2+ channels.
The Journal of neuroscience : the official journal of the Society for Neuroscience - 24 Dec 2008
Zhang Yun, Chen Yu-Hang, Bangaru Saroja D, He Linling, Abele Kathryn, Tanabe Shihori, Kozasa Tohru, Yang Jian
Abstract excerpt
G-protein (Gbetagamma)-mediated voltage-dependent inhibition of N- and P/Q-type Ca(2+) channels contributes to presynaptic inhibition and short-term synaptic plasticity. The voltage dependence derives from the dissociation of Gbetagamma from the inhibited channels, but the underlying molecular and biophysical mechanisms remain largely unclear. In this study we investigated the role in this process of Ca(2+)...
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