Article
Direct binding of G-protein betagamma complex to voltage-dependent calcium channels.
Nature - 30 Jan 1997
De Waard M, Liu H, Walker D, Scott V E, Gurnett C A, Campbell K P
Abstract excerpt
Voltage-dependent Ca2+ channels play a central role in controlling neurotransmitter release at the synapse. They can be inhibited by certain G-protein-coupled receptors, acting by a pathway intrinsic to the membrane. Here we show that this inhibition results from a direct interaction between the G-protein betagamma complex and the pore-forming alpha1 subunits of several types of these channels. The interaction is...
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