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Article

Molecular determinants for modulation of persistent sodium current by G-protein betagamma subunits.

The Journal of neuroscience : the official journal of the Society for Neuroscience - 30 Mar 2005

Mantegazza Massimo, Yu Frank H, Powell Andrew J, Clare Jeffrey J, Catterall William A, Scheuer Todd

Abstract excerpt

Voltage-gated sodium channels are responsible for the upstroke of the action potential in most excitable cells, and their fast inactivation is essential for controlling electrical signaling. In addition, a noninactivating, persistent component of sodium current, I(NaP), has been implicated in integrative functions of neurons including threshold for firing, neuronal bursting, and signal integration. G-protein...

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Identifiers

PMID: 15800189
DOI: 10.1523/JNEUROSCI.0104-05.2005
PMCID: PMC6724911

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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