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Article

The guanylate kinase domain of the beta-subunit of voltage-gated calcium channels suffices to modulate gating.

Proceedings of the National Academy of Sciences of the United States of America - 16 Sept 2008

Gonzalez-Gutierrez Giovanni, Miranda-Laferte Erick, Nothmann Doreen, Schmidt Silke, Neely Alan, Hidalgo Patricia

Abstract excerpt

Inactivation of voltage-gated calcium channels is crucial for the spatiotemporal coordination of calcium signals and prevention of toxic calcium buildup. Only one member of the highly conserved family of calcium channel beta-subunits--Ca(V)beta--inhibits inactivation. This unique property has been attributed to short variable regions of the protein; however, here we report that this inhibition actually is...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 18776052
DOI: 10.1073/pnas.0806558105
PMCID: PMC2544601

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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