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Article

Ca(2+) channel inactivation heterogeneity reveals physiological unbinding of auxiliary beta subunits.

Biophysical journal - 1 Jul 2001

Restituito S, Cens T, Rousset M, Charnet P

Abstract excerpt

Voltage gated Ca(2+) channel (VGCC) auxiliary beta subunits increase membrane expression of the main pore-forming alpha(1) subunits and finely tune channel activation and inactivation properties. In expression studies, co-expression of beta subunits also reduced neuronal Ca(2+) channel regulation by heterotrimeric G protein. Biochemical studies suggest that VGCC beta subunits and G protein betagamma can compete...

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Identifiers

PMID: 11423397
DOI: 10.1016/S0006-3495(01)75682-2
PMCID: PMC1301494

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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