Article
Ca(2+) channel inactivation heterogeneity reveals physiological unbinding of auxiliary beta subunits.
Biophysical journal - 1 Jul 2001
Restituito S, Cens T, Rousset M, Charnet P
Abstract excerpt
Voltage gated Ca(2+) channel (VGCC) auxiliary beta subunits increase membrane expression of the main pore-forming alpha(1) subunits and finely tune channel activation and inactivation properties. In expression studies, co-expression of beta subunits also reduced neuronal Ca(2+) channel regulation by heterotrimeric G protein. Biochemical studies suggest that VGCC beta subunits and G protein betagamma can compete...
Topics
- Animals
- Blotting, Western
- Calcium Channels
- Electrophysiology
- Enkephalin, Ala(2)-MePhe(4)-Gly(5)-
- Mutation
- Oocytes
- Protein Binding
- Protein Subunits
- Recombinant Proteins
- Xenopus laevis