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Article

Schizosaccharomyces pombe replication protein Cdc45/Sna41 requires Hsk1/Cdc7 and Rad4/Cut5 for chromatin binding.

Chromosoma - 1 Sept 2004

Dolan William P, Sherman Daniel A, Forsburg Susan L

Abstract excerpt

Cdc45 is a conserved protein required for firing of replication origins and processive DNA replication. We used an in situ chromatin-binding assay to determine factors required for fission yeast Cdc45p chromatin binding. Assembly of the pre-replicative complex is essential for Cdc45p chromatin binding, but pre-replicative complex assembly occurs independently of Cdc45p. Fission yeast Cdc45p associates with MCM...

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Source

Identifiers

PMID: 15338237
DOI: 10.1007/s00412-004-0302-8

Genes

CDC7

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Schizosaccharomyces pombe replication protein Cdc45/Sna41 requires Hsk1/Cdc7 and Rad4/Cut5 for chromatin binding.PMID 15338237Read ↗

Cdc45 protein-single-stranded DNA interaction is important for stalling the helicase during replication stress.Semantic proximity Read ↗

SpSld3 is required for loading and maintenance of SpCdc45 on chromatin in DNA replication in fission yeast.Semantic proximity Read ↗

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DBF4, not DRF1, is the crucial regulator of CDC7 kinase at replication forksSemantic proximity Read ↗

Actin nucleators safeguard replication forks by limiting nascent strand degradationSemantic proximity Read ↗

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Domain within the helicase subunit Mcm4 integrates multiple kinase signals to control DNA replication initiation and fork progression.Semantic proximity Read ↗

Fission yeast cut5+, required for S phase onset and M phase restraint, is identical to the radiation-damage repair gene rad4+.Semantic proximity Read ↗

A screen for Schizosaccharomyces pombe mutants defective in rereplication identifies new alleles of rad4+, cut9+ and psf2+.Semantic proximity Read ↗

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Active Replication Checkpoint Drives Genome Instability in Fission Yeast mcm4 Mutant.Semantic proximity Read ↗

Mcm4 C-terminal domain of MCM helicase prevents excessive formation of single-stranded DNA at stalled replication forks.Semantic proximity Read ↗

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