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Ordered assembly of Sld3, GINS and Cdc45 is distinctly regulated by DDK and CDK for activation of replication origins.

The EMBO journal - 4 Oct 2006

Yabuuchi Hayato, Yamada Yoshiki, Uchida Tomonori, Sunathvanichkul Tul, Nakagawa Takuro, Masukata Hisao

Abstract excerpt

Initiation of chromosome DNA replication in eukaryotes is tightly regulated through assembly of replication factors at replication origins. Here, we investigated dependence of the assembly of the initiation complex on particular factors using temperature-sensitive fission yeast mutants. The psf3-1 mutant, a GINS component mutant, arrested with unreplicated DNA at the restrictive temperature and the DNA content...

Topics

Cell Cycle Proteins
Chromosomes, Fungal
Cyclin-Dependent Kinases
DNA-Binding Proteins
Models, Genetic
Multiprotein Complexes
Mutation
Nuclear Proteins
Protein Serine-Threonine Kinases
Protein Transport

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Replication Origin

S Phase

Schizosaccharomyces

Schizosaccharomyces pombe Proteins

Source

Open in PubMed Open full text

Identifiers

PMID: 16990792
DOI: 10.1038/sj.emboj.7601347
PMCID: PMC1589995

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

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Ordered assembly of Sld3, GINS and Cdc45 is distinctly regulated by DDK and CDK for activation of replication origins.PMID 16990792Read ↗

SpSld3 is required for loading and maintenance of SpCdc45 on chromatin in DNA replication in fission yeast.Semantic proximity Read ↗

CDK promotes interactions of Sld3 and Drc1 with Cut5 for initiation of DNA replication in fission yeast.Semantic proximity Read ↗

GINS inactivation phenotypes reveal two pathways for chromatin association of replicative alpha and epsilon DNA polymerases in fission yeast.Semantic proximity Read ↗

Schizosaccharomyces pombe replication protein Cdc45/Sna41 requires Hsk1/Cdc7 and Rad4/Cut5 for chromatin binding.Semantic proximity Read ↗

Conserved mechanism for coordinating replication fork helicase assembly with phosphorylation of the helicase.Semantic proximity Read ↗

A screen for Schizosaccharomyces pombe mutants defective in rereplication identifies new alleles of rad4+, cut9+ and psf2+.Semantic proximity Read ↗

Concerted activities of Mcm4, Sld3, and Dbf4 in control of origin activation and DNA replication fork progression.Semantic proximity Read ↗

Crystal structure of the GINS complex and functional insights into its role in DNA replication.Semantic proximity Read ↗

Domain within the helicase subunit Mcm4 integrates multiple kinase signals to control DNA replication initiation and fork progression.Semantic proximity Read ↗

Checkpoint independence of most DNA replication origins in fission yeast.Semantic proximity Read ↗

Dbf4 recruitment by forkhead transcription factors defines an upstream rate-limiting step in determining origin firing timing.Semantic proximity Read ↗

The intra-S phase checkpoint directly regulates replication elongation to preserve the integrity of stalled replisomes.Semantic proximity Read ↗

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