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Article

Discrete determinants in ArfGAP2/3 conferring Golgi localization and regulation by the COPI coat.

Molecular biology of the cell - 1 Feb 2009

Kliouchnikov Lena, Bigay Joëlle, Mesmin Bruno, Parnis Anna, Rawet Moran, Goldfeder Noga, Antonny Bruno, Cassel Dan

Abstract excerpt

From yeast to mammals, two types of GTPase-activating proteins, ArfGAP1 and ArfGAP2/3, control guanosine triphosphate (GTP) hydrolysis on the small G protein ADP-ribosylation factor (Arf) 1 at the Golgi apparatus. Although functionally interchangeable, they display little similarity outside the catalytic GTPase-activating protein (GAP) domain, suggesting differential regulation. ArfGAP1 is controlled by membrane...

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Identifiers

PMID: 19109418
DOI: 10.1091/mbc.e08-10-1010
PMCID: PMC2633400

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Discrete determinants in ArfGAP2/3 conferring Golgi localization and regulation by the COPI coat.PMID 19109418Read ↗

Kinetic analysis of Arf GAP1 indicates a regulatory role for coatomer.Semantic proximity Read ↗

Role of coatomer and phospholipids in GTPase-activating protein-dependent hydrolysis of GTP by ADP-ribosylation factor-1.Semantic proximity Read ↗

ADP-Ribosylation factor 1 (ARF1) regulates recruitment of the AP-3 adaptor complex to membranes.Semantic proximity Read ↗

Two lipid-packing sensor motifs contribute to the sensitivity of ArfGAP1 to membrane curvature.Semantic proximity Read ↗

ARFGAP1 plays a central role in coupling COPI cargo sorting with vesicle formation.Semantic proximity Read ↗

Golgi localization determinants in ArfGAP1 and in new tissue-specific ArfGAP1 isoforms.Semantic proximity Read ↗

Multiple phosphorylation events regulate the subcellular localization of GGA1.Semantic proximity Read ↗

GGAs: a family of ADP ribosylation factor-binding proteins related to adaptors and associated with the Golgi complex.Semantic proximity Read ↗

Effects of activated ADP-ribosylation factors on Golgi morphology require neither activation of phospholipase D1 nor recruitment of coatomer.Semantic proximity Read ↗

Specific regulation of the adaptor protein complex AP-3 by the Arf GAP AGAP1.Semantic proximity Read ↗

COP I domains required for coatomer integrity, and novel interactions with ARF and ARF-GAP.Semantic proximity Read ↗

A conserved N-terminal arginine-motif in GOLPH3-family proteins mediates binding to coatomer.Semantic proximity Read ↗

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