Article
Golgi localization determinants in ArfGAP1 and in new tissue-specific ArfGAP1 isoforms.
The Journal of biological chemistry - 17 Feb 2006
Parnis Anna, Rawet Moran, Regev Lior, Barkan Batya, Rotman Miriam, Gaitner Michal, Cassel Dan
Abstract excerpt
The Arf1-directed GTPase-activating protein ArfGAP1 is a Golgi-localized protein that controls the dynamics of the COPI coat of carriers that mediate transport in the endoplasmic reticulum-Golgi shuttle. Previously the interaction of ArfGAP1 with the Golgi was allocated to a portion of the non-catalytic, carboxyl part of the protein, but the mechanism of this interaction has not been established. In this study we...
Topics
- Amino Acid Motifs
- Amino Acid Sequence
- Conserved Sequence
- GTPase-Activating Proteins
- Golgi Apparatus
- HeLa Cells
- Humans
- Molecular Sequence Data
- Mutation
- Organ Specificity
- Protein Isoforms