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Article

Two lipid-packing sensor motifs contribute to the sensitivity of ArfGAP1 to membrane curvature.

Biochemistry - 20 Feb 2007

Mesmin Bruno, Drin Guillaume, Levi Sharon, Rawet Moran, Cassel Dan, Bigay Joëlle, Antonny Bruno

Abstract excerpt

ArfGAP1 (Arf GTPase activating protein 1) controls the cycling of the COPI coat on Golgi membranes by catalyzing GTP hydrolysis in the small G protein Arf1. ArfGAP1 contains a central motif named ALPS (ArfGAP1 lipid-packing sensor) that adsorbs preferentially onto highly curved membranes. This motif allows coupling of the rate of GTP hydrolysis in Arf1 with membrane curvature induced by the COPI coat. Upon...

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PMID: 17253781
DOI: 10.1021/bi062288w

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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