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Article

Effects of activated ADP-ribosylation factors on Golgi morphology require neither activation of phospholipase D1 nor recruitment of coatomer.

The Journal of biological chemistry - 11 Feb 2000

Kuai J, Boman A L, Arnold R S, Zhu X, Kahn R A

Abstract excerpt

Nine mutations in the switch I and switch II regions of human ADP-ribosylation factor 3 (ARF3) were isolated from loss-of-interaction screens, using two-hybrid assays with three different effectors. We then analyzed the ability of the recombinant proteins to (i) bind guanine nucleotides, (ii) activate phospholipase D1 (PLD1), (iii) recruit coatomer (COP-I) to Golgi-enriched membranes, and (iv) expand and...

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Source

Identifiers

PMID: 10660559
DOI: 10.1074/jbc.275.6.4022

Genes

PLD1
ARF3

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Effects of activated ADP-ribosylation factors on Golgi morphology require neither activation of phospholipase D1 nor recruitment of coatomer.PMID 10660559Read ↗

Discrete determinants in ArfGAP2/3 conferring Golgi localization and regulation by the COPI coat.Semantic proximity Read ↗

Shared and specific functions of Arfs 1–5 at the Golgi revealed by systematic knockoutsSemantic proximity Read ↗

ADP ribosylation factor 1 mutants identify a phospholipase D effector region and reveal that phospholipase D participates in lysosomal secretion but is not sufficient for recruitment of coatomer I.Semantic proximity Read ↗

ADP-Ribosylation factor 1 (ARF1) regulates recruitment of the AP-3 adaptor complex to membranes.Semantic proximity Read ↗

ADP-ribosylation factors (ARFs) and ARF-like 1 (ARL1) Have Both Specific and Shared EffectorsSemantic proximity Read ↗

Recruitment of Arf1-GDP to Golgi by Glo3p-type ArfGAPs is crucial for golgi maintenance and plant growth.Semantic proximity Read ↗

A family of Arf effectors defined as suppressors of the loss of Arf function in the yeast Saccharomyces cerevisiae.Semantic proximity Read ↗

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