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Article

Role of coatomer and phospholipids in GTPase-activating protein-dependent hydrolysis of GTP by ADP-ribosylation factor-1.

The Journal of biological chemistry - 4 Aug 2000

Szafer E, Pick E, Rotman M, Zuck S, Huber I, Cassel D

Abstract excerpt

The binding of the coat protein complex, coatomer, to the Golgi is mediated by the small GTPase ADP-ribosylation factor-1 (ARF1), whereas the dissociation of coatomer, requires GTP hydrolysis on ARF1, which depends on a GTPase-activating protein (GAP). Recent studies demonstrate that when GAP activity is assayed in a membrane-free environment by employing an amino-terminal truncation mutant of ARF1 (Delta17-ARF1)...

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Identifiers

PMID: 10811810
DOI: 10.1074/jbc.M003171200

Genes

ARF1

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Research trail→

Click a neighbor to travelStep 1 · 12 closest

Role of coatomer and phospholipids in GTPase-activating protein-dependent hydrolysis of GTP by ADP-ribosylation factor-1.PMID 10811810Read ↗

Kinetic analysis of Arf GAP1 indicates a regulatory role for coatomer.Semantic proximity Read ↗

Discrete determinants in ArfGAP2/3 conferring Golgi localization and regulation by the COPI coat.Semantic proximity Read ↗

ARFGAP1 plays a central role in coupling COPI cargo sorting with vesicle formation.Semantic proximity Read ↗

A role for BARS at the fission step of COPI vesicle formation from Golgi membrane.Semantic proximity Read ↗

Direct and GTP-dependent interaction of ADP ribosylation factor 1 with coatomer subunit beta.Semantic proximity Read ↗

COP I domains required for coatomer integrity, and novel interactions with ARF and ARF-GAP.Semantic proximity Read ↗

ADP ribosylation factor 1 mutants identify a phospholipase D effector region and reveal that phospholipase D participates in lysosomal secretion but is not sufficient for recruitment of coatomer I.Semantic proximity Read ↗

Cooperation of GGAs and AP-1 in packaging MPRs at the trans-Golgi network.Semantic proximity Read ↗

ADP-Ribosylation factor 1 (ARF1) regulates recruitment of the AP-3 adaptor complex to membranes.Semantic proximity Read ↗

Dissection of membrane dynamics of the ARF-guanine nucleotide exchange factor GBF1.Semantic proximity Read ↗

Multiple phosphorylation events regulate the subcellular localization of GGA1.Semantic proximity Read ↗

Scission of COPI and COPII vesicles is independent of GTP hydrolysis.Semantic proximity Read ↗

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