Article
ARFGAP1 plays a central role in coupling COPI cargo sorting with vesicle formation.
The Journal of cell biology - 17 Jan 2005
Lee Stella Y, Yang Jia-Shu, Hong Wanjin, Premont Richard T, Hsu Victor W
Abstract excerpt
Examining how key components of coat protein I (COPI) transport participate in cargo sorting, we find that, instead of ADP ribosylation factor 1 (ARF1), its GTPase-activating protein (GAP) plays a direct role in promoting the binding of cargo proteins by coatomer (the core COPI complex). Activated ARF1 binds selectively to SNARE cargo proteins, with this binding likely to represent at least a mechanism by which...
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