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Article

Non-canonical functions of SNAIL drive context-specific cancer progression

7 Mar 2023

Abstract excerpt

Abstract SNAIL is a key transcriptional regulator in embryonic development and cancer. Its effects in physiology and disease are believed to be linked to its role as a master regulator of epithelial-to-mesenchymal transition (EMT). Here, we report EMT-independent oncogenic SNAIL functions in cancer. Using genetic models, we systematically interrogated SNAIL effects in various oncogenic backgrounds and tissue...

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PMID: 36882420
DOI: 10.1038/s41467-023-36505-0

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