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Article

Dual regulation of Snail by GSK-3beta-mediated phosphorylation in control of epithelial-mesenchymal transition.

Nature cell biology - 1 Oct 2004

Zhou Binhua P, Deng Jiong, Xia Weiya, Xu Jihong, Li Yan M, Gunduz Mehmet, Hung Mien-Chie

Abstract excerpt

The phenotypic changes of increased motility and invasiveness of cancer cells are reminiscent of the epithelial-mesenchymal transition (EMT) that occurs during embryonic development. Snail, a zinc-finger transcription factor, triggers this process by repressing E-cadherin expression; however, the mechanisms that regulate Snail remain elusive. Here we find that Snail is highly unstable, with a short half-life...

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PMID: 15448698
DOI: 10.1038/ncb1173

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

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Dual regulation of Snail by GSK-3beta-mediated phosphorylation in control of epithelial-mesenchymal transition.PMID 15448698Read ↗

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