Article
A gene expression signature associated with "K-Ras addiction" reveals regulators of EMT and tumor cell survival.
Cancer cell - 2 Jun 2009
Singh Anurag, Greninger Patricia, Rhodes Daniel, Koopman Louise, Violette Sheila, Bardeesy Nabeel, Settleman Jeff
Abstract excerpt
K-ras mutations occur frequently in epithelial cancers. Using short hairpin RNAs to deplete K-Ras in lung and pancreatic cancer cell lines harboring K-ras mutations, two classes were identified-lines that do or do not require K-Ras to maintain viability. Comparing these two classes of cancer cells revealed a gene expression signature in K-Ras-dependent cells, associated with a well-differentiated epithelial...
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