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Article

Mutant K-Ras activation of the proapoptotic MST2 pathway is antagonized by wild-type K-Ras.

Molecular cell - 23 Dec 2011

Matallanas David, Romano David, Al-Mulla Fahd, O'Neill Eric, Al-Ali Waleed, Crespo Piero, Doyle Brendan, Nixon Colin, Sansom Owen, Drosten Matthias, Barbacid Mariano, Kolch Walter

Abstract excerpt

K-Ras mutations are frequent in colorectal cancer (CRC), albeit K-Ras is the only Ras isoform that can elicit apoptosis. Here, we show that mutant K-Ras directly binds to the tumor suppressor RASSF1A to activate the apoptotic MST2-LATS1 pathway. In this pathway LATS1 binds to and sequesters the u...

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Source

Identifiers

PMID: 22195963
DOI: 10.1016/j.molcel.2011.10.016

Genes

LATS1
EGF
EGFR

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-22195963-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

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