Article
Antitumor effect of novel small chemical inhibitors of Snail-p53 binding in K-Ras-mutated cancer cells.
Oncogene - 12 Aug 2010
Lee S-H, Shen G-N, Jung Y S, Lee S-J, Chung J-Y, Kim H-S, Xu Y, Choi Y, Lee J-W, Ha N-C, Song G Y, Park B-J
Abstract excerpt
p53 is frequently mutated by genetic alternation or suppressed by various kinds of cellular signaling pathways in human cancers. Recently, we have revealed that p53 is suppressed and eliminated from cells by direct binding with oncogenic K-Ras-induced Snail. On the basis of the fact, we generated specific inhibitors against p53-Snail binding (GN25 and GN29). These chemicals can induce p53 expression and functions...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.