Article
Autophagy inhibition specifically promotes epithelial-mesenchymal transition and invasion in RAS-mutated cancer cells.
Autophagy - 1 May 2019
Wang Yihua, Xiong Hua, Liu Dian, Hill Charlotte, Ertay Ayse, Li Juanjuan, Zou Yanmei, Miller Paul, White Eileen, Downward Julian, Goldin Robert D, Yuan Xianglin, Lu Xin
Abstract excerpt
Macroautophagy/autophagy inhibition is a novel anticancer therapeutic strategy, especially for tumors driven by mutant RAS. Here, we demonstrate that autophagy inhibition in RAS-mutated cells induces epithelial-mesenchymal transition (EMT), which is associated with enhanced tumor invasion. This is at least partially achieved by triggering the NFKB/NF-κB pathway via SQSTM1/p62. Knockdown of ATG3 or ATG5 increases...
Read the complete abstract on PubMedTopics
- Antineoplastic Agents
- Autophagy
- Autophagy-Related Protein 5
- Autophagy-Related Proteins
- Cell Line, Tumor