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Article

Negative and positive regulation of MAPK phosphatase 3 controls platelet-derived growth factor-induced Erk activation.

The Journal of biological chemistry - 13 Feb 2009

Jurek Aleksandra, Amagasaki Kenichi, Gembarska Agnieszka, Heldin Carl-Henrik, Lennartsson Johan

Abstract excerpt

MAPK phosphatases (MKPs) are dual specificity phosphatases that dephosphorylate and thereby inactivate MAPKs. In the present study, we provide evidence that platelet-derived growth factor BB (PDGF-BB) regulates MKP3 (DUSP6), which is considered to be a phosphatase highly selective for Erk. Intriguingly, we observed that Mek is positively regulated by MKP3, whereas Erk itself is negatively regulated. In addition,...

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Source

Identifiers

PMID: 19106095
DOI: 10.1074/jbc.M808490200

Genes

DUSP6

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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