Article
Suppressor of cytokine signaling 3 negative regulation of signal transducer and activator of transcription 3 in platelet-derived growth factor-induced fibroblast migration.
The Journal of dermatology - 1 Aug 2007
Nagai Hiroshi, Tokumaru Sho, Sayama Koji, Shirakata Yuji, Hanakawa Yasushi, Hirakawa Satoshi, Dai Xiuju, Tohyama Mikiko, Yang Lujun, Hashimoto Koji
Abstract excerpt
Platelet-derived growth factor (PDGF) is involved in wound healing, but PDGF-induced fibroblast migration and the intracellular signaling mechanisms of fibroblast migration are poorly understood. Signal transducer and activator of transcription 3 (STAT3) is involved in migration and is negatively regulated by the suppressor of cytokine signaling 3 (SOCS3). We studied the PDGF induction of fibroblast migration in...
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