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Article

JNK pathway-associated phosphatase dephosphorylates focal adhesion kinase and suppresses cell migration.

The Journal of biological chemistry - 19 Feb 2010

Li Ju-Pi, Fu Yu-Ning, Chen Yi-Rong, Tan Tse-Hua

Abstract excerpt

JNK pathway-associated phosphatase (JKAP, also named DUSP22) is expressed in various tissues, indicating that JKAP may have an important biological function. We showed that JKAP localized in the actin filament-enriched region. Expression of JKAP reduced cell migration, whereas a JKAP mutant lacking catalytic activity promoted cell motility. JKAP efficiently removed tyrosine phosphorylation of several proteins. We...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 20018849
DOI: 10.1074/jbc.M109.060186
PMCID: PMC2820775

Genes

DUSP22

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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