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Article

Dusp6 (Mkp3) is a negative feedback regulator of FGF-stimulated ERK signaling during mouse development.

Development (Cambridge, England) - 1 Jan 2007

Li Chaoying, Scott Daryl A, Hatch Ekaterina, Tian Xiaoyan, Mansour Suzanne L

Abstract excerpt

Mitogen-activated protein kinase (MAPK) pathways are major mediators of extracellular signals that are transduced to the nucleus. MAPK signaling is attenuated at several levels, and one class of dual-specificity phosphatases, the MAPK phosphatases (MKPs), inhibit MAPK signaling by dephosphorylating activated MAPKs. Several of the MKPs are themselves induced by the signaling pathways they regulate, forming...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Extracellular Signal-Regulated MAP Kinases

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Source

Open in PubMed Open full text

Identifiers

PMID: 17164422
DOI: 10.1242/dev.02701
PMCID: PMC2424197

Genes

DUSP6

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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