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Article

Signal control through Raf: in sickness and in health.

Cell research - 1 Jan 2012

Osborne Jihan K, Zaganjor Elma, Cobb Melanie H

Abstract excerpt

The extracellular signal-regulated kinase 1/2 (ERK1/2) cascade is the prototype mammalian mitogen-activated protein kinase (MAPK) signaling cascade that regulates a number of processes, including proliferation, differentiation, survival, migration, stress responses and apoptosis. How this seemingly linear cascade is modulated to achieve a specific cellular function has been a main focus of the field. In this...

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Identifiers

PMID: 22143568
DOI: 10.1038/cr.2011.193
PMCID: PMC3351917

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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