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Article

Extensive purifying selection acting on synonymous sites in HIV-1 Group M sequences.

Virology journal - 23 Dec 2008

Ngandu Nobubelo K, Scheffler Konrad, Moore Penny, Woodman Zenda, Martin Darren, Seoighe Cathal

Abstract excerpt

BACKGROUND: Positive selection pressure acting on protein-coding sequences is usually inferred when the rate of nonsynonymous substitution is greater than the synonymous rate. However, purifying selection acting directly on the nucleotide sequence can lower the synonymous substitution rate. This could result in false inference of positive selection because when synonymous changes at some sites are under purifying...

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Identifiers

PMID: 19105834
DOI: 10.1186/1743-422X-5-160
PMCID: PMC2666660

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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