More effective purifying selection on RNA viruses than in DNA viruses.

doi:10.1016/j.gene.2007.09.013

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Article

More effective purifying selection on RNA viruses than in DNA viruses.

Gene - 1 Dec 2007

Hughes Austin L, Hughes Mary Ann K

Abstract excerpt

Analysis of the pattern of nucleotide diversity in 222 independent viral sequence datasets showed the prevalence of purifying selection. In spite of the higher mutation rate of RNA viruses, our analyses revealed stronger evidence of the action of purifying selection in RNA viruses than in DNA viruses. The ratio of nonsynonymous to synonymous nucleotide diversity was significantly lower in RNA viruses than in DNA...

Topics

Animals
DNA Viruses
Genome, Viral
Mutation
Polymorphism, Genetic
RNA Viruses
Selection, Genetic

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Identifiers

PMID: 17928171
DOI: 10.1016/j.gene.2007.09.013
PMCID: PMC2756238

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