Article
Codon-based detection of positive selection can be biased by heterogeneous distribution of polar amino acids along protein sequences.
Computational systems bioinformatics. Computational Systems Bioinformatics Conference - 1 Jan 2006
Xia Xuhua, Kumar Sudhir
Abstract excerpt
The ratio of the number of nonsynonymous substitutions per site (Ka) over the number of synonymous substitutions per site (Ks) has often been used to detect positive selection. Investigators now commonly generate Ka/Ks ratio profiles in a sliding window to look for peaks and valleys in order to identify regions under positive selection. Here we show that the interpretation of peaks in the Ka/Ks profile as...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.