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Article

Global synonymous mutagenesis identifies cis-acting RNA elements that regulate HIV-1 splicing and replication.

PLoS pathogens - 1 Jan 2018

Takata Matthew A, Soll Steven J, Emery Ann, Blanco-Melo Daniel, Swanstrom Ronald, Bieniasz Paul D

Abstract excerpt

The ~9.5 kilobase HIV-1 genome contains RNA sequences and structures that control many aspects of viral replication, including transcription, splicing, nuclear export, translation, packaging and reverse transcription. Nonetheless, chemical probing and other approaches suggest that the HIV-1 genome may contain many more RNA secondary structures of unknown importance and function. To determine whether there are...

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Identifiers

PMID: 29377940
DOI: 10.1371/journal.ppat.1006824
PMCID: PMC5805364

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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