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Article

Positive selection acting on splicing motifs reflects compensatory evolution.

Genome research - 1 Apr 2008

Ke Shengdong, Zhang Xiang H-F, Chasin Lawrence A

Abstract excerpt

We have used comparative genomics to characterize the evolutionary behavior of predicted splicing regulatory motifs. Using base substitution rates in intronic regions as a calibrator for neutral change, we found a strong avoidance of synonymous substitutions that disrupt predicted exonic splicing enhancers or create predicted exonic splicing silencers. These results attest to the functionality of the hexameric...

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Identifiers

PMID: 18204002
DOI: 10.1101/gr.070268.107
PMCID: PMC2279241

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Positive selection acting on splicing motifs reflects compensatory evolution.PMID 18204002Read ↗

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