A simple method for estimating the intensity of purifying selection in protein-coding genes.

doi:10.1093/oxfordjournals.molbev.a026037

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Article

A simple method for estimating the intensity of purifying selection in protein-coding genes.

Molecular biology and evolution - 1 Jan 1999

Ophir R, Itoh T, Graur D, Gojobori T

Abstract excerpt

We propose a method by which the intensity of purifying selection on a functional protein-coding gene is estimated by using three aligned homologous sequences: a processed pseudogene (psi), a functional paralog from the same species (g), and a functional ortholog from a different species (o). For each such trio, we calculate the numbers of nucleotide substitutions along the branches leading to psi and g, i.e., K...

Topics

Animals
Evolution, Molecular
Genes
Genetic Techniques
Humans
Mice
Mutation
Proteins
Pseudogenes
Selection, Genetic
Species Specificity

Source

Open in PubMed

Identifiers

PMID: 10331251
DOI: 10.1093/oxfordjournals.molbev.a026037

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