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Article

Role of the dosR-dosS two-component regulatory system in Mycobacterium tuberculosis virulence in three animal models.

Infection and immunity - 1 Mar 2009

Converse Paul J, Karakousis Petros C, Klinkenberg Lee G, Kesavan Anup K, Ly Lan H, Allen Shannon Sedberry, Grosset Jacques H, Jain Sanjay K, Lamichhane Gyanu, Manabe Yukari C, McMurray David N, Nuermberger Eric L, Bishai William R

Abstract excerpt

The Mycobacterium tuberculosis dosR gene (Rv3133c) is part of an operon, Rv3134c-Rv3132c, and encodes a response regulator that has been shown to be upregulated by hypoxia and other in vitro stress conditions and may be important for bacterial survival within granulomatous lesions found in tuberculosis. DosR is activated in response to hypoxia and nitric oxide by DosS (Rv3132c) or DosT (Rv2027c). We compared the...

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Identifiers

PMID: 19103767
DOI: 10.1128/IAI.01117-08
PMCID: PMC2643651

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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