Article
Individual Mycobacterium tuberculosis universal stress protein homologues are dispensable in vitro.
Tuberculosis (Edinburgh, Scotland) - 1 Jul 2010
Hingley-Wilson S M, Lougheed K E A, Ferguson K, Leiva S, Williams H D
Abstract excerpt
Mycobacterium tuberculosis has 10 universal stress proteins, whose function is unknown. However, proteomic and transcriptomic analyses have shown that a number of usp genes are significantly upregulated under hypoxic conditions and in response to nitric oxide and carbon monoxide, as well as during M. tuberculosis infection of macrophage cell lines. Six of these USPs are part of the DosR regulon and this, along...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.