Article
Expansion of the human mu-opioid receptor gene architecture: novel functional variants.
Human molecular genetics - 15 Mar 2009
Shabalina Svetlana A, Zaykin Dmitri V, Gris Pavel, Ogurtsov Aleksey Y, Gauthier Josee, Shibata Kyoko, Tchivileva Inna E, Belfer Inna, Mishra Bikashkumar, Kiselycznyk Carly, Wallace Margaret R, Staud Roland, Spiridonov Nikolay A, Max Mitchell B, Goldman David, Fillingim Roger B, Maixner William, Diatchenko Luda
Abstract excerpt
The mu-opioid receptor (OPRM1) is the principal receptor target for both endogenous and exogenous opioid analgesics. There are substantial individual differences in human responses to painful stimuli and to opiate drugs that are attributed to genetic variations in OPRM1. In searching for new functional variants, we employed comparative genome analysis and obtained evidence for the existence of an expanded human...
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