Bioinformatic analysis of the human mu opioid receptor (OPRM1) splice and polymorphic variants.

doi:10.1208/ps040423

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Article

Bioinformatic analysis of the human mu opioid receptor (OPRM1) splice and polymorphic variants.

AAPS pharmSci - 1 Jan 2002

Xin Lili, Wang Zaijie Jim

Abstract excerpt

Mu opioid receptor (OPRM1), a member of the G-protein coupled receptor superfamily, mediates the analgesic and euphoric effects of opioid drugs. The sequences of OPRM1 cDNA and reported splice variants were used to search the public and Celera genomic databases. The matched sequences were analyzed to assemble an OPRM1 genomic contig. Human OPRM1 gene was estimated to span at least 90 kb in the chromosome 6q24-25...

Topics

Alternative Splicing
Computational Biology
DNA, Complementary
Exons
Humans
Introns
Molecular Sequence Data
Molecular Weight
Polymorphism, Single Nucleotide
Receptors, Opioid, mu
Sequence Analysis, DNA

Source

Open in PubMed Open full text

Identifiers

PMID: 12645995
DOI: 10.1208/ps040423
PMCID: PMC2751312

Genes

OPRM1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026.

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