Cis-Expression Quantitative Trait Loci Mapping Reveals Replicable Associations with Heroin Addiction in OPRM1.

doi:10.1016/j.biopsych.2015.01.003

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Cis-Expression Quantitative Trait Loci Mapping Reveals Replicable Associations with Heroin Addiction in OPRM1.

Biological psychiatry - 1 Oct 2015

Hancock Dana B, Levy Joshua L, Gaddis Nathan C, Glasheen Cristie, Saccone Nancy L, Page Grier P, Hulse Gary K, Wildenauer Dieter, Kelty Erin A, Schwab Sibylle G, Degenhardt Louisa, Martin Nicholas G, Montgomery Grant W, Attia John, Holliday Elizabeth G, McEvoy Mark, Scott Rodney J, Bierut Laura J, Nelson Elliot C, Kral Alex H, Johnson Eric O

Abstract excerpt

BACKGROUND: No opioid receptor, mu 1 (OPRM1) gene polymorphisms, including the functional single nucleotide polymorphism (SNP) rs1799971, have been conclusively associated with heroin/other opioid addiction, despite their biological plausibility. We used evidence of polymorphisms altering OPRM1 expression in normal human brain tissue to nominate and then test associations with heroin addiction. METHODS: We tested...

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PMID: 25744370
DOI: 10.1016/j.biopsych.2015.01.003
PMCID: PMC4519434

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OPRM1

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

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