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Article

Alternative Splicing of Opioid Receptor Genes Shows a Conserved Pattern for 6TM Receptor Variants.

Cellular and molecular neurobiology - 1 Jul 2021

Piltonen Marjo, Krokhotin Andrey, Parisien Marc, Bérubé Pierre, Djambazian Haig, Sladek Rob, Dokholyan Nikolay V, Shabalina Svetlana A, Diatchenko Luda

Abstract excerpt

The opioid receptor (OPR) family comprises the mu-, delta-, and kappa-opioid, and nociceptin receptors that belong to the superfamily of 7-transmembrane spanning G protein-coupled receptors (GPCRs). The mu-opioid receptor is the main target for clinically used opioid analgesics, and its biology has been extensively studied. The N-terminally truncated 6TM receptors isoform produced through alternative splicing of...

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Identifiers

PMID: 33010019
DOI: 10.1007/s10571-020-00971-7
PMCID: PMC8159799

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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